Population
Mice (wild-type, apo-E-deficient, and targeted mutagenesis models)
Comparison
Targeted mutagenesis of the apo-B gene to… vs Wild-type mice fed a chow diet
Design
Preclinical
Authors
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Apo-B48 sufficiency for normal development with distinct lipid effects in mice leaves open isoform-specific roles in human atherosclerosis.
Targeted mutagenesis creating mice that exclusively express apo-B48 or apo-B100 demonstrates that apo-B48 is sufficient for normal development and reveals distinct effects on plasma lipid profiles.
Farese et al. (1996) studied this question.
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