Why the study?
Does substituting apoB-48 with apoB-100 improve the type-III hyperlipoproteinemia phenotype in Apoe(2/2) mice?
Population
Apoe(2/2) mice (mice expressing APOE*2 in place of mouse Apoe)
Comparison
Crossing with Apobec mice to produce Apoe.Apobec… vs Apoe(2/2) mice (expressing apoB-48)
Design
Preclinical
Authors
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Does not support apoB isoform substitution for type III hyperlipoproteinemia; leaves open differential apoB effects on human lipoprotein catabolism.
Does substituting apoB-48 with apoB-100 improve the type-III hyperlipoproteinemia phenotype in Apoe(2/2) mice?
In a mouse model of type-III hyperlipoproteinemia, substituting apoB-48 with apoB-100 did not improve the phenotype because the two apolipoproteins differentially influence lipoprotein catabolism.
Hinsdale et al. (2002) studied this question.
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