Population
19-day gestational mice and newborn suckling mice genetically deficient in the ability to synthesize apoB in…
Comparison
Genetic deficiency in intestinal apoB synthesis vs Normal control mice
Design
Preclinical
Authors
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Suggests apoB is required for chylomicron ER exit in mice; leaves open relevance to human intestinal lipid disorders.
In vivo evidence suggests chylomicron formation involves synthesizing apoB-free triglyceride-rich particles in the ER lumen, with apoB required for their transport to the Golgi apparatus.
Hamilton et al. (1998) studied this question.
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