Key result
The human fetal colon synthesizes apolipoproteins A-I, A-IV, B-48, and B-100, and their synthesis is modulated by hydrocortisone, insulin, and epidermal growth factor.
Population
Human fetal colon tissue
Design
Preclinical
Authors
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May indicate extrahepatic apolipoprotein synthesis in fetal development; leaves open physiological role and clinical translation.
The human fetal colon has the capacity to synthesize apolipoproteins A-I, A-IV, B-48, and B-100, and their synthesis is modulated by hormonal and growth factors.
Basque et al. (1998) studied Human fetal colon development. Hydrocortisone, insulin, and epidermal growth factor (EGF) was evaluated on Apolipoprotein synthesis and localization. The human fetal colon synthesizes apolipoproteins A-I, A-IV, B-48, and B-100, and their synthesis is modulated by hydrocortisone, insulin, and epidermal growth factor.
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