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July 1, 1999Journal of Lipid ResearchOpen Access

Isolated rabbit enterocytes as a model cell system for investigations of chylomicron assembly and secretion

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Population

Isolated viable enterocytes from rabbit small intestine

Comparison

Addition of bile salt/lipid micelles vs No lipid micelles

Design

Preclinical

Authors

ICIan J. CartwrightUniversity of SheffieldJHJoan A. HigginsLAC+USC Medical Center

Discussion

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Implication

Does not inform clinical lipid management; validates rabbit enterocytes as a model for chylomicron assembly studies.

Structured PICO

P
Population
Isolated viable enterocytes from rabbit small intestine
I
Intervention
Addition of bile salt/lipid micelles
C
Comparator
No lipid micelles (implied in pulse-chase experiments)
O
Outcome
Synthesis, secretion, and intracellular degradation of apoB-48 and triacylglycerolsurrogate

Isolated rabbit enterocytes serve as a useful model system for investigating the molecular mechanisms of chylomicron assembly and secretion.

Cite This Study

Cartwright et al. (1999) studied this question.

synapsesocial.com/papers/6a78691fa0847c3df1ecdbd4https://doi.org/10.1016/s0022-2275(20)33498-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Apolipoprotein B synthesis by human liver and intestine in vitro.1986 · 130 citations
  2. 2ROLE OF LIPID SYNTHESIS, CHAPERONE PROTEINS AND PROTEASOMES IN THE ASSEMBLY AND SECRETION OF APOPROTEIN B‐CONTAINING LIPOPROTEINS FROM CULTURED LIVER CELLS1997 · 47 citations
  3. 3Intracellular movement of triacylglycerols in the intestine1998 · 97 citations
  4. 4Electron microscopic study of intestinal fat absorption in vitro from mixed micelles containing linolenic acid, monoolein, and bile salt1966 · 127 citations
  5. 5Cloning and regulation of hamster microsomal triglyceride transfer protein. The regulation is independent from that of other hepatic and intestinal proteins which participate in the transport of fatty acids and triglycerides.1994 · 106 citations