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January 1, 2003Frontiers in bioscienceOpen Access

Mechanisms of metabolic dyslipidemia in insulin resistant states deregulation of hepatic and intestinal lipoprotein secretion

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Population

In vitro and in vivo models of insulin resistance (including the fructose-fed hamster model) and human studies

Design

Review

Authors

KAKhosrow AdeliPreventive Cardiology

Discussion

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Implication

Extends mechanistic insights into metabolic dyslipidemia; leaves open whether targeting oversecretion alters outcomes in insulin resistance.

Structured PICO

P
Population
In vitro and in vivo models of insulin resistance (including the fructose-fed hamster model) and human studies
O
Outcome
Mechanisms of hypertriglyceridemia and overproduction of apolipoprotein B (apoB)-containing lipoproteins

This review highlights that metabolic dyslipidemia in insulin resistance is driven by a complex interaction of enhanced free fatty acid flux, hyperinsulinemia, and attenuated insulin signaling leading to hepatic and intestinal lipoprotein overproduction.

Cite This Study

Khosrow Adeli (2003) studied this question.

synapsesocial.com/papers/6a735d6664cdd4095c2c282dhttps://doi.org/10.2741/1022
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enhanced expression of hepatic acyl-coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation1998 · 88 citations
  2. 2Glucose-stimulated insulin secretion suppresses hepatic triglyceride-rich lipoprotein and apoB production2000 · 88 citations
  3. 3The apolipoprotein B gene is constitutively expressed in HepG2 cells: regulation of secretion by oleic acid, albumin, and insulin, and measurement of the mRNA half-life.1989 · 415 citations
  4. 4Insulin resistance and lipoprotein metabolism1995 · 131 citations
  5. 5Protein Tyrosine Phosphatases: A Diverse Family of Intracellular and Transmembrane Enzymes1991 · 969 citations