May 10, 2017DiseasesOpen Access

Targeting Metabolic Modulation and Mitochondrial Dysfunction in the Treatment of Heart Failure

View Full Paper

Ask AI

Bookmark

Population

Patients with heart failure

Design

Review

Authors

ASAbbey SteggallFlinders University IMIfy MordiHeart Failure / Cardiomyopathy CLChim C. LangHeart Failure / Cardiomyopathy

Discussion

Member takes

Implication

Targeting myocardial energetics in HF remains investigational; leaves open whether mitochondrial therapies improve outcomes beyond current standards.

Structured PICO

Population

Patients with heart failure

Intervention

Metabolic therapeutics (trimetazidine, ranolazine, perhexiline) and mitochondrial-targeting pharmaceuticals (elamipretide)

Metabolic modulators and mitochondrial-targeting drugs represent a promising emerging therapeutic approach for heart failure, though large randomized trials are still needed.

Cite This Study

Steggall et al. (2017) studied this question.

synapsesocial.com/papers/6a735db429b0f29a5dc67f2b https://doi.org/10.3390/diseases5020014

View Full Paper

Ask AI

Bookmark

Implication

Targeting myocardial energetics in HF remains investigational; leaves open whether mitochondrial therapies improve outcomes beyond current standards.

Targeting Metabolic Modulation and Mitochondrial Dysfunction in the Treatment of Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Targeting Metabolic Modulation and Mitochondrial Dysfunction in the Treatment of Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider