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Hetero Diels-Alder reaction of aromatic aldoximes with different alkenes resulted in highly substituted dihydroisoxazoles (1-12) in good yields. All the compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H37Ra and H37Rv. Compounds 2, 3, 6, and 10 exhibited antitubercular activity with minimum inhibitory concentration (MIC) ranging from 12.5 to 3.12 g/mL against the infectious strain M. tuberculosis H37Rv.
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Bisht et al. (2010) studied this question.