Gene targeting in mice has elucidated the distinct physiological roles of angiotensin II receptor subtypes in blood pressure regulation and development.
Does not support clinical changes in renin-angiotensin blockade; leaves open translation of mouse receptor insights to human hypertension.
The study of mice with targeted disruptions of angiotensin receptor genes has provided new insights into the roles of the individual receptor subtypes, i.e., AT(1A), AT(1B), and AT(2), in growth, development, and the regulation of blood pressure.
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Oliverio et al. (2000) studied this question.
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