The antigenicity of Murine Sarcoma Virus (MSV) transformed mouse, rat and hamster cells has been studied by several techniques designed to detect surface antigens. Antigens were readily demonstrated on neoplastic mouse and rat cells. There was complete cross‐reactivity between cells induced by the Harvey (MSV‐H) or Moloney (MSV‐M) strains of MSV and by Moloney Leukemia Virus (MLV). No evidence of a distinct or separate „MSV‐non‐MLV”︁ antigen could be obtained by cross absorptions of MSV/MLV antisera and cells, or by tests designed to break MLV tolerance. Such results favor the view that MSV and MLV are closely related entities. With the 8303 line of MSV‐M transformed hamster cells serological tests revealed little if any reactivity with strongly positive mouse anti‐MSV/MLV antisera. In one test, however, immunization of mice with these cells gave some degree of protection against syngeneic MSV sarcoma.
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Chuat et al. (1969) studied this question.
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