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January 1, 1968ThoraxOpen Access

Bacterial endocarditis, mitral regurgitation, and intra-atrial thrombosis following mitral valve replacement

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Why the study?

Does an extensive antibiotic regime prevent bacterial endocarditis and intra-atrial thrombosis in patients undergoing mitral valve replacement?

Population

260 patients undergoing mitral valve replacement

Comparison

Extensive antibiotic regime described by Amoury… vs Previous standard care without the specific…

Design

Cohort

Follow-up

1 year for the intervention cohort

Authors

HWHarry M. WindsorHonda (Japan)PFPaul FaganUniversity of SheffieldMSMark X. ShanahanUniversity of Surrey

Discussion

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Implication

Amoury regime was associated with zero events in this cohort; hypothesis-generating and requires RCTs before changing prophylaxis practice.

Structured PICO

Does an extensive antibiotic regime prevent bacterial endocarditis and intra-atrial thrombosis in patients undergoing mitral valve replacement?

P
Population
260 patients undergoing mitral valve replacement (140 in an initial series, 120 in a subsequent consecutive series)
I
Intervention
Extensive antibiotic regime described by Amoury and colleagues
C
Comparator
Previous standard care without the specific antibiotic regime (historical control)
O
Outcome
Incidence of bacterial endocarditis, intra-atrial thrombosis, and wound infectionhard clinical

An extensive antibiotic regime effectively eliminated bacterial endocarditis and intra-atrial thrombosis following mitral valve replacement in this historical cohort.

Cite This Study

Windsor et al. (1968) studied this question.

synapsesocial.com/papers/6a7362bd1158a4b73a5662ddhttps://doi.org/10.1136/thx.23.1.11
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