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A 64-year-old woman was found to have pulmonary lymphoreticular infiltration associated with a cryoprecipitate monoclonal paraprotein. History and investigation suggested that these features may have complicated long-standing immunodeficiency. Subsequent postmortem revealed a lymphocytic lymphoma of the lung and stomach. It is postulated that pulmonary lymphoreticular infiltration and monoclonal paraproteinemia might be a consequence of defective immunoregulation with excessive B cell proliferation. The eventual lymphoma is thought to represent malignant transformation.
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Richmond et al. (1981) studied this question.
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