Key result
Polypill therapy cuts 5-year stroke incidence ~50% in primary prevention.
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This review summarizes the potential for polypill therapies for stroke prevention. While a number of studies applying different approaches regarding polypill have been performed, none of them has had a focus on stroke as the main outcome. A combination pill containing drugs such as statins, diuretics, and other antihypertensives is currently available in various formats. Estimates focusing mostly on primary prevention show that using such a combination drug a reduction in the 5-year stroke incidence by 50% can be achieved - especially in low- and middle-income countries with a high prevalence of risk factors even among people at young ages. A combination of a large supporting population-wide program with a registry-based quality control is the most likely perspective and can be achieved within a reasonable time frame and potentially have significant influence in young stroke populations.
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Brainin et al. (2018) conducted a review in Primary prevention of stroke. Polypill (combination pill containing statins, diuretics, and other antihypertensives) was evaluated on 5-year stroke incidence (50% reduction). Polypill therapy containing statins, diuretics, and antihypertensives is estimated to achieve a 50% reduction in 5-year stroke incidence for primary prevention.
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