Why the study?
Do clinical features, risk factors, and in-hospital outcomes differ between young (≤ 45 years) and non-young (> 45 years) patients with acute myocardial infarction?
Do clinical features, risk factors, and in-hospital outcomes differ between young (≤ 45 years) and non-young (> 45 years) patients with acute myocardial infarction?
Young patients with acute myocardial infarction present with a distinct clinical profile driven heavily by modifiable risk factors such as smoking, hyperlipidemia, and being overweight, emphasizing the need for targeted early prevention strategies.
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Identifies modifiable risks in young AMI; hypothesis-generating for prevention but requires prospective validation before practice change.
Clinical features and outcomes of acute myocardial infarction (AMI) in the young have been poorly investigated. The aim of this study was to investigate the clinical features and hospital outcomes of AMI in young Japanese. We conducted a case-control study. A total of 53 consecutive AMI patients whose age was ≤ 45 years old were assigned to the young group and 106 AMI patients whose age was > 45 years old were assigned to the non-young group. We compared the clinical features and hospital outcomes between the two groups. Compared with the non-young group, the young group was associated with male sex, hyperlipidemia, current smoking, being overweight, single vessel disease, and Killip class I on admission. There were no differences in the length of hospital stay or major adverse cardiac events between the groups. However, mortality and ventricular rupture were slightly lower in the young. In conclusion, young AMI patients had clinical characteristics different to those of the non-young patients. Compared to non-young patients, modifiable risk factors such as smoking, hyperlipidemia, and being overweight were associated with young AMI patients.
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Jinnouchi et al. (2013) studied this question.
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