Analysis of clinical characteristics and risk factors of young acute myocardial infarction

OBJECTIVE: The aim of the study is to investigate the clinical characteristics and risk factors for the development of young acute myocardial infarction (AMI). METHODS: A number of 196 AMI patients (31 young patients and 165 older patients) were enrolled in the study. The clinical characteristics in young AMI patients were explored by comparing their baseline characteristics, imaging features and serological results. The risk factors were tested by logistics regression analysis. RESULTS: The younger AMI patients were more likely to have hyperlipidaemia (67.74% vs. 36.97%, P=0.002), a family history of coronary heart disease and hyperlipidaemia (29.03% vs. 12.12%, P=0.025) (51.61% vs. 18.79%, P<0.001), (54.84% vs. 35.15%, P=0.045) (61.29% vs. 34.55%, P=0.008). The proportion of alcohol and tobacco use were higher in younger AMI group. More severe anterior descending lesions involvement (77.42% vs. 46.06%, P=0.002) and a higher Gensini scores (62.23±16.80) vs. (53.00±18.58), P=0.011) were found in CTA imagines of younger AMI patients. The triglyceride levels were also significantly higher in younger AMI patients (2.55±1.59) vs. (1.67±0.79), P=0.005). A family history of hyperlipidaemia, Gensini score, IL-6 and triglycerides were risk factors for young AMI patients. CONCLUSION: Poor lifestyle management and family history were risk factors for the AMI development in young patients.