Why the study?
Does extrinsically induced nocturnal nondipping lower daytime blood pressure in healthy subjects?
Population
12 healthy sleeping subjects
Comparison
Continuously infused phenylephrine during sleep… vs Isotonic saline (control condition)
Design
Other
Follow-up
3 hours after resuming physical activity
Authors
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Does not support inducing nondipping in patients; hypothesis-generating for baroreflex resetting during sleep.
Does extrinsically induced nocturnal nondipping lower daytime blood pressure in healthy subjects?
Preventing nocturnal blood pressure dipping with phenylephrine paradoxically lowers morning blood pressure by resetting the baroreflex set point, supporting a central mechanism for blood pressure resetting during sleep.
Sayk et al. (2007) studied this question.
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