What question did this study set out to answer?

To review current knowledge on COVID-19 and pulmonary fibrosis, focusing on cellular mechanisms involving lung epithelial cells and fibroblasts that may drive long-term lung scarring.

May 24, 2021Immunological ReviewsOpen Access

COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts

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Authors

AJAlison E. JohnNIHR Imperial Biomedical Research Centre CJChitra JosephUniversity of Nottingham GJGísli JenkinsImperial College London

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Implication

Narrative review highlights shared fibrotic pathways in post-COVID-19 patients, indicating potential cellular mechanisms driving progressive lung damage.

Key Points

To review current knowledge on COVID-19 and pulmonary fibrosis, focusing on cellular mechanisms involving lung epithelial cells and fibroblasts that may drive long-term lung scarring.
Narrative review evaluating published literature on SARS-CoV-2 pathogenesis and the molecular etiology of interstitial pulmonary fibrosis.
Synthesized evidence concerning cellular interactions, tissue remodeling dynamics, and pathways shared between viral injury and progressive fibrotic lung disease.
SARS-CoV-2 infection can lead to persistent features of interstitial pulmonary fibrosis following severe acute respiratory distress syndrome.
Interactions between injured lung epithelial cells and activated fibroblasts represent common pathways that likely regulate whether post-COVID-19 fibrotic damage resolves or becomes progressive.

Cite This Study

John et al. (2021) studied this question.

synapsesocial.com/papers/6a736b39644e61a44f4e5ba9 https://doi.org/10.1111/imr.12977

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Implication

Narrative review highlights shared fibrotic pathways in post-COVID-19 patients, indicating potential cellular mechanisms driving progressive lung damage.

COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts

Discussion

Member takes

Implication

Key Points

Cite This Study

COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts

Discussion

Member takes

Implication

Key Points

Cite This Study

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