⌘+K

Pulse Explore Clubs Researchers Journals

Home Clubs Explore

March 9, 2013Critical Care Medicine

Macrophage Migration Inhibitory Factor Induces Contractile and Mitochondria Dysfunction by Altering Cytoskeleton Network in the Human Heart*

Sébastien Préau David Montaigne Thomas Modine Georges Fayad Mohamed Koussa Meryem Tardivel Alain Durocher F. Saulnier Xavier Maréchal Rémi Nevière

View Full Paper

Ask AI

Bookmark

Share

Structured PICO

P

Population

Human myocardial (atrial) trabeculae obtained at the time of cardiac surgery

I

Intervention

Macrophage migration inhibitory factor (MIF) (100 ng/mL) for 60 minutes, with or without pretreatment with colchicine (10 µM) or paclitaxel (10 µM)

C

Comparator

Controls (unexposed trabeculae)

O

Outcome

Maximal active isometric tension curve, developed isometric force, mitochondrial respiration, and sarcomere/microtubule disarraysurrogate

MIF induces contractile and mitochondrial dysfunction in human myocardium by altering microtubule dynamics and activating the AMPK pathway.

Implication

MIF-induced myocardial dysfunction may involve microtubule dynamics in models; hypothesis-generating and should not yet inform clinical practice.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Préau et al. (2013) studied this question.

synapsesocial.com/papers/6a736c438412e8bdfca7281e https://doi.org/10.1097/ccm.0b013e31827c0d8c

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Macrophage migration inhibitory factor in atrial fibrillationreview · 2026
2Macrophage Migration Inhibitory Factor Inhibition Is Deleterious for High-Fat Diet-Induced Cardiac Dysfunctionpreclinical · 2013 · 6 citations
3Macrophage migration inhibitory factor plays a permissive role in the maintenance of cardiac contractile function under starvation through regulation of autophagypreclinical · 2013 · 57 citations
4Macrophage migration inhibitory factor deficiency augments cardiac dysfunction in Type 1 diabetic murine cardiomyocytespreclinical · 2010 · 18 citations
5Lack of Macrophage Migration Inhibitory Factor Reduces Susceptibility to Ventricular Arrhythmias During the Acute Phase of Myocardial Infarctionpreclinical · 2021 · 8 citations