May 1, 2003DiabetesOpen Access

Hepatic VLDL Production in ob/ob Mice Is Not Stimulated by Massive De Novo Lipogenesis but Is Less Sensitive to the Suppressive Effects of Insulin

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Population

female ob/ob mice and lean controls

Comparison

Hyperinsulinemic clamping vs lean controls

Design

Preclinical

Authors

CWCoen WiegmanImperial College London RBRobert BandsmaUniversity of Malawi DOD. Margriet OuwensLeiden University

Discussion

Member takes

Implication

Insulin suppression of VLDL production is impaired in obese mice; hypothesis-generating for hepatic insulin resistance in human dyslipidemia.

Structured PICO

Population

female ob/ob mice and lean controls

Intervention

Hyperinsulinemic clamping

Comparator

lean controls

Outcome

VLDL-triglyceride and -apolipoprotein (apo)-B production ratessurrogate

In ob/ob mice, strongly induced hepatic de novo lipogenesis does not increase VLDL production, but insulin fails to effectively suppress VLDL-triglyceride production due to impaired insulin signaling.

Cite This Study

Wiegman et al. (2003) studied this question.

synapsesocial.com/papers/6a736db06cf7a6ca1f6c351b https://doi.org/10.2337/diabetes.52.5.1081

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Implication

Insulin suppression of VLDL production is impaired in obese mice; hypothesis-generating for hepatic insulin resistance in human dyslipidemia.

Hepatic VLDL Production in ob/ob Mice Is Not Stimulated by Massive De Novo Lipogenesis but Is Less Sensitive to the Suppressive Effects of Insulin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hepatic VLDL Production in ob/ob Mice Is Not Stimulated by Massive De Novo Lipogenesis but Is Less Sensitive to the Suppressive Effects of Insulin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider