Population
Rat engineered heart tissue (EHT) subjected to spontaneous contractile activity and electrical pacing
Comparison
77 drugs tested at 1, 10, and 100 times free… vs Baseline conditions
Design
Preclinical
Follow-up
45 min incubation steps per concentration
Authors
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Rat EHT may aid Ito/IKs proarrhythmia detection; leaves open its standalone TdP screening utility given IKr insensitivity.
Rat engineered heart tissue can detect proarrhythmic effects mediated by Ito and IKs, but its insensitivity to IKr limits its utility as a standalone general proarrhythmia screen.
Eder et al. (2014) studied this question.
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