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Summary Antibacterial antibody response was studied in rabbits that were experimentally infected with staphylococci so as to simulate human endocarditis and osteomyelitis. Sera from rabbits inoculated intravenously twice weekly for 4 weeks contained high titers of opsonic, agglutinating, and complement-fixing antibodies. In a second group of rabbits, single intramedullary inoculations of staphylococci successfully produced osteomyelitis. These animals also developed high titers of opsonic and agglutinating antibodies. The titers of complement-fixing antibodies were generally lower in rabbits with experimental osteomyelitis than they were in animals with recurrent bacteremia. Opsonic antibodies were specifically and completely absorbed by the infecting strain of Staphylococcus aureus. No evidence was obtained for “leukophilic” γ globulin with phagocytosis-promoting activity. Sucrose gradient fractionation of immune rabbit sera indicated that the primary heat-stable opsonin was 7 S γG.
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Nickerson et al. (1969) studied this question.
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