N-Terminal Amino Acid Sequences of Pepsinogens from Dogfish and Seal and of Bovine Pepsinogen B.

Per Klemm; F. Reibke Poulsen; Marianne Harboe; Bent Foltmann; A. Taticchi; T. Anthonsen

doi:10.3891/acta.chem.scand.30b-0979

January 1, 1976Acta chemica Scandinavica/Acta chemica Scandinavica. B, Organic chemistry and biochemistry/Acta chemica Scandinavica. A, Physical and inorganic chemistry/Acta chemica Scandinavica. Series B. Organic chemistry and biochemistry/Acta chemica Scandinavica. Series A, Physical and inorganic chemistryOpen Access

N-Terminal Amino Acid Sequences of Pepsinogens from Dogfish and Seal and of Bovine Pepsinogen B.

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Key Points

To determine and compare the N-terminal amino acid sequences of pepsinogens isolated from dogfish, seal, and cattle.
Determined the N-terminal amino acid residues of dogfish pepsinogen (8 residues), seal pepsinogen (26 residues), and bovine pepsinogen B (25 residues).
Compared the resulting primary structures against previously characterized gastric protease zymogen sequences.
Successfully mapped the N-terminal segments: 8 residues for dogfish, 26 residues for seal, and 25 residues for bovine pepsinogen B.
Identified considerable structural homology across all three pepsinogen sequences relative to known gastric protease zymogens.

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Implication

Biochemical analysis reveals high sequence homology among dogfish, seal, and bovine pepsinogens, suggesting conserved evolutionary origins of gastric zymogens.

Abstract

The N-terminal amino acid sequences of dogfish pepsinogen (8 residues), seal pepsinogen (26 residues) and bovine pepsinogen B (25 residues) have been determined. The primary structures of all three pepsinogens show considerable homology with those of zymogens of gastric proteases sequenced previously.

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Klemm et al. (1976) studied this question.

synapsesocial.com/papers/6a7373df50ef228d5e6c3496 https://doi.org/10.3891/acta.chem.scand.30b-0979

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N-Terminal Amino Acid Sequences of Pepsinogens from Dogfish and Seal and of Bovine Pepsinogen B.

Key Points

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Implication

Abstract

Discussion

Cite This Study

N-Terminal Amino Acid Sequences of Pepsinogens from Dogfish and Seal and of Bovine Pepsinogen B.

Key Points

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Implication

Abstract

Discussion

Cite This Study

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