Why the study?
Does intra-arterial cis-diammine-dichloroplatinum II (CDP) produce a clinical response in pediatric patients with osteosarcoma?
Population
11 pediatric patients with osteosarcoma and 1 with malignant fibrous histiocytoma (total n=12)
Design
Case_series
Authors
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Supports exploration of intra-arterial CDP in pediatric osteosarcoma; hypothesis-generating and should not yet change practice.
Does intra-arterial cis-diammine-dichloroplatinum II (CDP) produce a clinical response in pediatric patients with osteosarcoma?
Intra-arterial CDP at 150 mg/m2 is safe and effective in producing a clinical response and tumor destruction in pediatric osteosarcoma due to high local drug concentration and tumor penetration.
Jaffe et al. (1983) studied this question.
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