April 1, 1984Journal of Clinical Oncology
Interferons in the treatment of human cancer.
Authors
Discussion
Loading...
Member takes
Implication
Randomized trial evaluates interferons in treating human cancer, suggesting potential clinical benefits.
Key Points
- To summarize the clinical potential of interferons in treating cancer and examine their effects.
- Reviewed phase I and II trial results of interferons in various disease states.
- Described dosage and effects of naturally and bacterially produced interferons.
- Studied mechanisms related to antiviral, antiproliferative, and immunologic functions.
- Interferons show a wide range of biologic effects both in vitro and in vivo.
- Maximally tolerated dosages were established for common species of interferon alpha.
- Antiviral and immunologic functions of interferons may enhance clinical outcomes in cancer treatment.
Cite This Study
Kirkwood et al. (1984) studied this question.