What question did this study set out to answer?

The research aims to evaluate the effects of clopidogrel and ticlopidine on platelet adhesion and intimal proliferation following arterial injury in rabbits.

August 1, 1993Arteriosclerosis and Thrombosis A Journal of Vascular Biology

Inhibitory effect of clopidogrel on platelet adhesion and intimal proliferation after arterial injury in rabbits.

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Why the study?

Does clopidogrel or ticlopidine reduce platelet adhesion and intimal proliferation after arterial injury in rabbits?

Population

Rabbit platelets in vitro and rabbits subjected to air-drying endothelial injury of the carotid artery

Comparison

Clopidogrel or ticlopidine vs Aspirin (100-200 mg/kg PO) or untreated control

Design

Preclinical

Follow-up

16 days

Authors

JHJean‐Marc HerbertCross-Cutting Cardiology ATA TissinierSanofi (France)GDG. DefreynVisteon (South Korea)

Discussion

Member takes

Implication

Supports clopidogrel investigation in vascular injury models; leaves open translation to human restenosis prevention.

Key Points

The research aims to evaluate the effects of clopidogrel and ticlopidine on platelet adhesion and intimal proliferation following arterial injury in rabbits.
Rabbits were treated with clopidogrel (10 mg/kg), ticlopidine (200 mg/kg), or aspirin (200 mg/kg) to assess platelet adhesion in vitro and in vivo.
Platelet adhesion to the injured rabbit carotid artery was evaluated using air-drying injury to the vessel.
Intimal proliferation was assessed after a 16-day treatment with clopidogrel (25 mg/kg per day) and compared with ticlopidine and aspirin.
Clopidogrel administration resulted in 95% inhibition of platelet adhesion (P < .001) post-arterial injury.
Clopidogrel also inhibited intimal thickening by 48% (P < .01) after 16 days of treatment.
Ticlopidine showed 57% inhibition of myointimal thickening (P < .001), while aspirin demonstrated no significant effect.

Structured PICO

Does clopidogrel or ticlopidine reduce platelet adhesion and intimal proliferation after arterial injury in rabbits?

Population

Rabbit platelets in vitro and rabbits subjected to air-drying endothelial injury of the carotid artery

Intervention

Clopidogrel (10-25 mg/kg PO single dose or 25 mg/kg/day PO for 16 days) or ticlopidine (200 mg/kg PO)

Comparator

Aspirin (100-200 mg/kg PO) or untreated control

Outcome

Platelet adhesion to subendothelium and intimal smooth muscle hyperplasia (myointimal thickening)surrogate

Clopidogrel and ticlopidine effectively reduce platelet adhesion and subsequent myointimal thickening after endothelial injury in a rabbit model, whereas aspirin does not.

Cite This Study

Herbert et al. (1993) studied this question.

synapsesocial.com/papers/6a737a548317ef39e84e606c https://doi.org/10.1161/01.atv.13.8.1171

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Inhibitory effect of clopidogrel on platelet adhesion and intimal proliferation after arterial injury in rabbits.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Inhibitory effect of clopidogrel on platelet adhesion and intimal proliferation after arterial injury in rabbits.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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