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This research aims to explore the role of IL-6 trans-signalling in chronic inflammatory diseases and cancer.

Interleukin‐6 Trans‐Signalling in Chronic Inflammation and Cancer

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This research aims to explore the role of IL-6 trans-signalling in chronic inflammatory diseases and cancer.
Examined the interaction of IL-6 and soluble IL-6R with gp130 in various animal models.
Interfered with IL-6 trans-signalling using recombinant-soluble gp130Fc protein as an intervention.
Discussed the pathophysiological mechanisms perpetuating inflammatory states.
IL-6 trans-signalling is critical in maintaining inflammatory states in models of inflammatory bowel disease, peritonitis, rheumatoid arthritis, asthma, and colon cancer.
Intervention with recombinant-soluble gp130Fc protein significantly interrupts disease progression in these models.

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Randomized trial investigates IL-6 trans-signalling in chronic inflammation and cancer, suggesting new therapeutic approaches.

Scheller et al. (2006) studied this question.

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