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March 1, 1973

Arteriovenous differences of lactate and pyruvate across healthy and diseased human lung.

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Why the study?

Do diseased human lungs produce lactate compared to normal lungs?

Population

Patients with pulmonary tuberculosis or carcinoma, subjects with normal lungs, patients with widespread…

Comparison

Measurement of local and systemic arteriovenous… vs Subjects with normal lungs.

Design

Cross-sectional

Authors

DRDudley F. RochesterWWWalter A. WichernHFH. W. Fritts

Discussion

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Overview

Local sampling may unmask lactate production by diseased lung regions masked systemically; leaves open its contribution to systemic levels or clinical relevance.

Structured PICO

Do diseased human lungs produce lactate compared to normal lungs?

P
Population
Patients with pulmonary tuberculosis or carcinoma (n=14), subjects with normal lungs (n=8), patients with widespread active tuberculosis (n=4), and patients undergoing thoracotomy for tuberculosis or carcinoma (n=16).
I
Intervention
Measurement of local and systemic arteriovenous differences of lactate and pyruvate.
C
Comparator
Subjects with normal lungs.
O
Outcome
Arteriovenous differences of lactate and pyruvate concentrations.surrogate

Diseased lung tissue in tuberculosis or carcinoma produces lactate, which can be detected by local arteriovenous sampling but is often masked in systemic mixed venous samples.

Cite This Study

Rochester et al. (1973) studied this question.

synapsesocial.com/papers/6a7383a620644e164b4e5ef9https://doi.org/10.1164/arrd.1973.107.3.442
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lactate, pyruvate, glucose, and free fatty acid in mixed venous and arterial blood1963 · 25 citations
  2. 2RELATIONSHIPS OF PYRUVATE AND LACTATE DURING ANAEROBIC METABOLISM. I. EFFECTS OF INFUSION OF PYRUVATE OR GLUCOSE AND OF HYPERVENTILATION11958 · 673 citations
  3. 3Observations on a model of proliferative lung disease1970 · 22 citations
  4. 4<i>Control of Concentration Gradients of Pyruvate and Lactate Across Cell Membranes in Blood</i>1956 · 159 citations