Why the study?
Does Angiotensin-(1-7) reduce migration and invasion in A549 human lung adenocarcinoma cells?
Population
A549 human lung adenocarcinoma cells in vitro
Comparison
Angiotensin- at 25, 50, or 100 nM for 48 hours vs PBS control, or Ang- 100 nM combined with MAS…
Design
Preclinical, blinded fashion for cell counting
Follow-up
48 hours
Authors
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Does not alter lung adenocarcinoma management; hypothesis-generating for MAS agonism in metastasis research.
Does Angiotensin-(1-7) reduce migration and invasion in A549 human lung adenocarcinoma cells?
Angiotensin-(1-7) inhibits the migration and invasion of human lung adenocarcinoma cells in vitro by downregulating MMP-2 and MMP-9 via inactivation of PI3K/Akt and MAPK pathways.
Huanying Wan (2011) studied this question.
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