August 15, 2022International Journal of Pharmaceutical Sciences Review and ResearchOpen Access

Comparison of Haemodynamic Parameters in Patients on Calcium Channel Blockers and Beta Blockers Undergoing Subarachnoid Block

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Why the study?

Does the type of chronic antihypertensive therapy (calcium channel blockers vs beta blockers) affect hemodynamic stability in hypertensive patients undergoing subarachnoid block?

Population

Patients undergoing subarachnoid block for surgery

Comparison

Hypertensive patients on calcium channel blockers vs beta blockers vs normotensive patients

Follow-up

120 minutes

Authors

DPDr Ashish Prakash Prasad DPDr Gyan Prakash SDSweta DubeySUNY Downstate Health Sciences University

Discussion

Member takes

Implication

In patients undergoing subarachnoid block, those on chronic calcium channel blocker therapy are at higher risk for hypotension, while those on beta blockers are at higher risk for bradycardia.

Structured PICO

Does the type of chronic antihypertensive therapy (calcium channel blockers vs beta blockers) affect hemodynamic stability in hypertensive patients undergoing subarachnoid block?

Population

78 patients aged 20-60 years (ASA physical status I and II) undergoing elective surgeries under subarachnoid block, including 49 diagnosed with essential hypertension and 29 normotensive controls.

Intervention

Chronic therapy with calcium channel blockers (n=25) or beta blockers (n=24) for essential hypertension.

Comparator

Normotensive patients not on antihypertensive therapy (n=29).

Outcome

Hemodynamic parameters including Heart rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), and Mean Arterial Pressure (MAP) measured at baseline and 3, 6, 9, 15, 30, 45, 60, 75, 90, 105, and 120 minutes after the subarachnoid block.surrogate

In patients undergoing subarachnoid block, those on chronic calcium channel blocker therapy are at higher risk for hypotension, while those on beta blockers are at higher risk for bradycardia.

Limitations

Small sample size
Confined to a single centre
Impact of concomitant medication and co-morbidities was not assessed
Sub-group analysis was not done

Cite This Study

Prasad et al. (2022) studied this question.

synapsesocial.com/papers/6a7387d25946a55bc0fb69b6 https://doi.org/10.47583/ijpsrr.2022.v75i02.028

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Implication

In patients undergoing subarachnoid block, those on chronic calcium channel blocker therapy are at higher risk for hypotension, while those on beta blockers are at higher risk for bradycardia.

Comparison of Haemodynamic Parameters in Patients on Calcium Channel Blockers and Beta Blockers Undergoing Subarachnoid Block

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Comparison of Haemodynamic Parameters in Patients on Calcium Channel Blockers and Beta Blockers Undergoing Subarachnoid Block

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider