Why the study?
Does cotherapy with rabeprazole or esomeprazole affect the antiplatelet effect of clopidogrel in patients receiving clopidogrel 75 mg?
Population
n=239 consecutive patients receiving clopidogrel 75 mg, including 45 patients with CYP2C19 loss of function…
Comparison
Cotherapy with rabeprazole or esomeprazole added… vs Clopidogrel 75 mg alone
Design
Cohort
Authors
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Supports no attenuation by these PPIs or CYP2C19 variants; leaves open confirmation in randomized trials.
Does cotherapy with rabeprazole or esomeprazole affect the antiplatelet effect of clopidogrel in patients receiving clopidogrel 75 mg?
Neither CYP2C19*2 loss-of-function alleles nor concomitant use of esomeprazole or rabeprazole significantly attenuate the antiplatelet effect of clopidogrel.
El-Halabi et al. (2013) studied this question.
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