Why the study?
Approximately 20% of patients with Takotsubo syndrome develop left ventricular outflow tract obstruction, often with predisposing septal hypertrophy, but the underlying pathophysiology remains incompletely understood.
In a patient with Takotsubo syndrome and LVOTO, dobutamine stress echocardiography revealed latent LVOTO predisposed by a sigmoid septum, suggesting it may be a contributor rather than a bystander.
Approximately 20% of patients with Takotsubo syndrome (TTS) develop complications such as left ventricular outflow tract obstruction (LVOTO). The published data suggest that a significant proportion of these patients have predisposing septal hypertrophy or sigmoid septum. However, the pathophysiology regarding this connection has not yet been fully elucidated. We herein present the case of a 75-year-old female patient with TTS complicated by LVOTO, which was successfully managed. During the follow-up, mild basal septal hypertrophy was observed. Subsequent exercise and dobutamine stress echocardiography were performed to reveal the mechanism of LVOTO in TTS.
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Atanasković et al. (2025) studied this question.
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