Why the study?
To evaluate clinical and CMR characteristics, as well as in-hospital and long-term outcomes, in patients with Takotsubo syndrome and left ventricular outflow tract obstruction.
Does the presence of LVOTO increase the risk of in-hospital complications and long-term MACE in patients with Takotsubo syndrome?
Population
249 patients with Takotsubo syndrome undergoing CMR within 5 days of echocardiography
Comparison
Presence vs absence of LVOTO
Design
Multicenter retrospective registry sub-analysis
Key result
In patients with Takotsubo syndrome, left ventricular outflow tract obstruction was associated with increased in-hospital complications (34.6% vs 15.8%; OR 3.16, 95% CI 1.08-9.26, p=0.035).
Authors
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LVOTO in TTS may require tailored acute management to avoid worsening gradients; leaves open whether CMR features independently predict outcomes.
Cohort (n=249)
Yes
Does the presence of LVOTO increase the risk of in-hospital complications and long-term MACE in patients with Takotsubo syndrome?
In patients with Takotsubo syndrome, LVOTO is associated with greater myocardial edema and a higher risk of in-hospital complications, but not long-term MACE.
Odds Ratio: 3.16 (95% CI 1.08–9.26)
Absolute Event Rate: 34.6% vs 15.8%
p-value: p=0.035
Cau et al. (2026) conducted a cohort in Takotsubo syndrome (n=249). Left ventricular outflow tract obstruction (LVOTO) vs. Absence of LVOTO was evaluated on In-hospital complications (OR 3.16, 95% CI 1.08-9.26, p=0.035). In patients with Takotsubo syndrome, left ventricular outflow tract obstruction was associated with increased in-hospital complications (34.6% vs 15.8%; OR 3.16, 95% CI 1.08-9.26, p=0.035).