Key result
Left ventricular ejection fraction at admission was a significant independent predictor of major adverse cardiac events in patients with Takotsubo syndrome (HR 0.932), with LVEF <40% associated with poorer long-term outcomes.
Why the study?
The study aimed to evaluate short- and long-term outcomes in Takotsubo syndrome patients, seeking early identification of those with better prognosis and assessing LVEF recovery over time.
Cohort (n=49)
No
Hazard Ratio: 0.932 (95% CI 0.889–0.978)
p-value: p=0.004
Patients with Takotsubo syndrome presenting with LVEF <40% have a poorer long-term prognosis despite apparent complete recovery of left ventricular systolic function over time.
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Admission LVEF <40% identifies higher MACE risk in TTS; leaves open whether targeted strategies improve outcomes pending randomized data.
Licordari et al. (2021) conducted a cohort in Takotsubo syndrome (n=49). Left ventricular ejection fraction (LVEF) at admission vs. Higher LVEF was evaluated on Major adverse cardiac events (MACE), including cardiovascular death and re-hospitalizations for acute heart failure, atrial fibrillation, acute myocardial infarction, or TTS recurrence (HR 0.932, 95% CI 0.889-0.978, p=0.004). Left ventricular ejection fraction at admission was a significant independent predictor of major adverse cardiac events in patients with Takotsubo syndrome (HR 0.932), with LVEF <40% associated with poorer long-term outcomes.
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