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February 4, 2019European Journal of Heart Failure85 citationsOpen Access

Long-Term Outcome in Patients with Takotsubo Syndrome Presenting with Severely Reduced Left Ventricular Ejection Fraction

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Why the study?

Does severely reduced LVEF (≤ 35%) at presentation predict worse long-term outcomes in patients with Takotsubo syndrome?

Population

326 patients with Takotsubo syndrome enrolled in the Takotsubo Italian Network, mean age 69.5 ± 10.7 years…

Comparison

Severely reduced left ventricular ejection… vs LVEF > 35% at presentation

Design

Cohort

Follow-up

median 26.5 months

Authors

RCRodolfo CitroIRIlaria RadanoGPGuido Parodi

Discussion

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Member takes

Overview

Severe LVEF reduction at TTS presentation signals higher long-term MACE risk; supports closer surveillance but leaves open targeted intervention trials.

Structured PICO

Does severely reduced LVEF (≤ 35%) at presentation predict worse long-term outcomes in patients with Takotsubo syndrome?

P
Population
326 patients with Takotsubo syndrome (TTS) enrolled in the Takotsubo Italian Network, mean age 69.5 ± 10.7 years, 28 male.
I
Intervention
Severely reduced left ventricular ejection fraction (LVEF ≤ 35%) at presentation
C
Comparator
LVEF > 35% at presentation
O
Outcome
Composite major adverse cardiac events (MACE: cardiac death, acute myocardial infarction, heart failure, and TTS recurrence) and rehospitalization at median 26.5 months follow-upcomposite

Severely reduced LVEF (≤ 35%) at presentation in Takotsubo syndrome is an independent predictor of long-term major adverse cardiac events.

Cite This Study

Citro et al. (2019) studied this question.

synapsesocial.com/papers/6a95207aa878998ea8e60daehttps://doi.org/10.1002/ejhf.1373
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