Why the study?
Data on the association between ejection fraction and mortality in patients with TTS compared with ACS were limited.
Does Takotsubo Syndrome compared to Acute Coronary Syndrome affect long-term mortality across different ejection fraction strata?
Does Takotsubo Syndrome compared to Acute Coronary Syndrome affect long-term mortality across different ejection fraction strata?
Takotsubo syndrome is associated with higher long-term mortality than acute coronary syndrome, predominantly driven by non-cardiovascular causes.
EF thresholds may aid risk stratification in TTS versus ACS; leaves open causal links and management thresholds.
BACKGROUND/AIM: The association between ejection fraction (EF) and mortality in TTS patients as compared to ACS is limited. This study aims to investigate the association between EF and clinical outcomes in patients with TTS as compared to ACS. PATIENTS AND METHODS: This study compared in-hospital, and long-term incidence of clinical outcomes for 5 years in patients with TTS and ACS. The study was composed of two groups EF≥35% and EF<35%. RESULTS: The long-term mortality of the EF≥35% for 5 years was significantly higher in TTS patients as compared to ACS (18.1% vs. 7.7%, log-Rank; p<0.01). Irrespective of EF, a non-cardiovascular death was significantly higher in TTS as compared to ACS patients with EF≥35 (6.4% vs. 2.1%; p=0.02) and with EF<35% (21.4% vs. 7.5%; p=0.03). CONCLUSION: The long-term mortality is significantly higher in TTS as compared to ACS dominated by a non-cardiovascular cause of death at 5-years-follow-up.
No takes yet. Share an insight, caveat, or question.
Abumayyaleh et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: