Why the study?
Does acute opioid withdrawal induced by naloxone increase opioid craving and seeking behavior in methadone-maintained volunteers?
Population
8 methadone-maintained volunteers
Comparison
Pretreatment with naloxone 0.1 mg/70 kg or… vs Saline iv pretreatment paired with…
Design
RCT, 3 x 2 within-subject randomized crossover design
Authors
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Naloxone-precipitated withdrawal increases craving and symptoms without boosting seeking; extends dissociation between subjective and operant responses in methadone-maintained OUD.
Does acute opioid withdrawal induced by naloxone increase opioid craving and seeking behavior in methadone-maintained volunteers?
Acute opioid withdrawal increases craving and withdrawal symptoms but does not significantly alter operant drug-seeking behavior in methadone-maintained individuals.
Mark K. Greenwald (2005) studied this question.
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