Recent Advances in C—H Bond Functionalization under Mechanochemical Conditions

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Mechanochemistry has received increasing attention in the past decade. Among which, the mechanochemical C-H bond functionalization has emerged as a hot research topic. In comparison with the traditional solution-based organic reactions, the mechanochemical transformation features solvent-less conditions and short reaction time, constituting a green and efficient synthetic method in the modern chemical society. Notably, given the outstanding features, some long-standing challenges in the previous solution-based reactions could be well-solved by mechanochemical methods. Therefore, a timely comprehensive overview to recognize the present status of the mechanochemical C-H bond functionalization is of great importance to stimulate the development of more efficient synthetic methods. In this review, the state of the art for mechanochemical C-H bond transformation is presented. The limitation in this research field is also analyzed and the outlook of this area is prospected.