Why the study?
Does Danshensu inhibit isoproterenol-induced cardiac fibrosis in neonatal rat cardiac fibroblasts?
Population
Neonatal rat cardiac fibroblasts (CFs) isolated from 1 to 2 day-old Sprague-Dawley rats
Comparison
Danshensu at various concentrations administered… vs Vehicle or isoproterenol (ISO) alone
Design
Preclinical
Follow-up
24 hours
Authors
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Hypothesis-generating for Danshensu in cardiac fibrosis; prospective studies needed before clinical consideration.
Does Danshensu inhibit isoproterenol-induced cardiac fibrosis in neonatal rat cardiac fibroblasts?
Danshensu inhibits β-adrenergic receptor-mediated cardiac fibroblast proliferation and collagen synthesis by negatively regulating the ROS-p38 MAPK signaling pathway.
Lu et al. (2014) studied this question.
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