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Does cilostazol inhibit proliferation and increase iNOS and p21 expression in cultured aortic vascular smooth muscle cells stimulated with PDGF-BB?
Does cilostazol inhibit proliferation and increase iNOS and p21 expression in cultured aortic vascular smooth muscle cells stimulated with PDGF-BB?
Cilostazol inhibits vascular smooth muscle cell proliferation through an iNOS-dependent p21 pathway, providing a potential mechanism for its ability to prevent restenosis after percutaneous coronary intervention.
Supports cilostazol's iNOS-p21 antiproliferative effect in VSMCs; leaves open translation to restenosis prevention after PCI.
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Lee et al. (2004) studied this question.
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