Why the study?
What are the normative effects of epinephrine and isoproterenol infusions on cardiac repolarization in healthy subjects?
Population
24 healthy subjects, mean age 29 +/- 8 years
Comparison
Graded infusions of epinephrine and isoproterenol vs Baseline measurements prior to infusion
Authors
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Establishes normative catecholamine effects on repolarization; supports paradoxical QT prolongation as specific LQTS criterion but leaves validation open.
What are the normative effects of epinephrine and isoproterenol infusions on cardiac repolarization in healthy subjects?
Both epinephrine and isoproterenol prolong QTc and amplify U waves in healthy subjects, indicating that paradoxical QT prolongation at low-dose epinephrine or QTc >=600 msec are highly specific criteria for diagnosing long-QT syndrome.
Magnano et al. (2006) studied this question.
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