What question did this study set out to answer?

To assess whether maternal serum cytokine levels can accurately identify histologic chorioamnionitis in women experiencing preterm labor.

February 26, 2010Gynecologic and Obstetric Investigation

Value of the Maternal Interleukin 6 Level for Determination of Histologic Chorioamnionitis in Preterm Delivery

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Authors

KMKazuhisa MaedaShikoku Medical Center for Children and Adults NMNoboru MatsuzakiOsaka City University SFShinji FukeOsaka Women's and Children's Hospital

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Implication

Cohort study demonstrates maternal interleukin-6 reliably detects histologic chorioamnionitis in preterm delivery, highlighting superior diagnostic value compared to C-reactive protein.

Key Points

To assess whether maternal serum cytokine levels can accurately identify histologic chorioamnionitis in women experiencing preterm labor.
Collected maternal blood samples at delivery from 29 women who delivered preterm between 22 and 34 weeks of gestation.
Histopathologically examined placentas for chorioamnionitis and measured serum levels of interleukin-6, C-reactive protein, interleukin-8, monocyte chemotactic and activating factor, and soluble interleukin-6 receptor.
Interleukin-6 was significantly elevated in mothers with histologic chorioamnionitis (n=18; median 12.0 pg/ml, range 4.9–63.5 pg/ml) compared to those without (n=11; median 3.5 pg/ml, range 1.7–14.9 pg/ml; p < 0.0001).
Interleukin-6 demonstrated a higher odds ratio for histologic chorioamnionitis (OR 9.78, 95% CI 1.50–63.82) than C-reactive protein (OR 3.26, 95% CI 1.22–8.67; median 5.2 mg/dl vs 0.2 mg/dl, p = 0.0001).
Levels of interleukin-8, monocyte chemotactic and activating factor, and soluble interleukin-6 receptor did not differ significantly between groups.

Cite This Study

Maeda et al. (2010) studied this question.

synapsesocial.com/papers/6a73967020644e164b4e6377 https://doi.org/10.1159/000291862

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Implication

Cohort study demonstrates maternal interleukin-6 reliably detects histologic chorioamnionitis in preterm delivery, highlighting superior diagnostic value compared to C-reactive protein.

Value of the Maternal Interleukin 6 Level for Determination of Histologic Chorioamnionitis in Preterm Delivery

Discussion

Member takes

Implication

Key Points

Cite This Study

Value of the Maternal Interleukin 6 Level for Determination of Histologic Chorioamnionitis in Preterm Delivery

Discussion

Member takes

Implication

Key Points

Cite This Study

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