Beneficial effect of vitamin E administration on nitric oxide function in subjects with hypercholesterolaemia

7 subjects aged 47+/-3 years with moderately elevated serum cholesterol concentrations (6.0+/-0.1 mmol/l)

Vitamin E 500 i.u. twice daily for 4 weeks

4 weeks of placebo therapy prior to vitamin E administration

Basal and stimulated function of the nitric oxide (NO) dilator system (endothelium-dependent and -independent vasodilatation assessed by forearm blood flow)surrogate