Why the study?
Does partial sleep deprivation alter intrinsic brain connectivity and global signal variability in young and older adults?
Population
53 healthy adults without psychiatric or neurological illness, hypertension, or diabetes.
Comparison
Partial sleep deprivation (3 hours of sleep) vs Full sleep (normal sleep)
Design
Other, Randomised to undergo both conditions in a counterbalanced order…
Authors
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Increased global signal variability after partial sleep deprivation warrants caution interpreting fMRI in sleepy patients; leaves open whether network changes are robust across ages.
Does partial sleep deprivation alter intrinsic brain connectivity and global signal variability in young and older adults?
Partial sleep deprivation increases global fMRI signal variability, potentially reflecting wake-state instability, without significantly altering resting state networks.
Nilsonne et al. (2017) studied this question.
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