May 20, 2025Reviews in Cardiovascular MedicineOpen Access

Association Between Cardiometabolic Index and Blood Pressure: A Cross-Sectional Analysis of the NHANES 2015–2018 Data

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Why the study?

Hypertension is closely related to metabolic abnormalities, but the relationship between the cardiometabolic index (CMI) and blood pressure remains poorly understood.

Does the cardiometabolic index correlate with clinical blood pressure in adults not taking antihypertensive medications?

Population

4240 participants from NHANES 2015 to 2018

Comparison

Cardiometabolic index levels

Design

Cross-sectional analysis

Authors

LHLingyan HeShaoxing People's Hospital LSLing SunZhejiang Chinese Medical University HPH. Y. PanYangtze University

Discussion

Member takes

Implication

CMI-BP association in cross-sectional data leaves open causality and clinical utility; prospective studies required before practice consideration.

Structured PICO

Does the cardiometabolic index correlate with clinical blood pressure in adults not taking antihypertensive medications?

Population

4,240 adults (≥18 years) from the US NHANES 2015–2018 database, mean age 48.85, 47.8% male. Key exclusions: taking antihypertensive medications, missing clinic blood pressure data, or missing data to calculate the cardiometabolic index.

Intervention

Cardiometabolic index (CMI), calculated as waist-to-height ratio × (triglycerides / HDL-C)

Comparator

Different levels of CMI (tertiles or continuous)

Outcome

Clinic systolic blood pressure (SBP) and diastolic blood pressure (DBP)surrogate

The cardiometabolic index has a significant, non-linear positive correlation with clinical blood pressure, suggesting its potential utility in personalized cardiovascular risk stratification.

Limitations

Cross-sectional nature of the NHANES data prevents determining causality from CMI to BP.
Unmeasured confounders such as genetic factors and psychosocial traits could potentially affect the relationship.
Application of the CMI formula in diverse populations needs further validation.
Missing information on smoking history for 2441 participants may have introduced bias.

Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/6a73a4111c100ebba7fb6bb7 https://doi.org/10.31083/rcm37359

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Implication

CMI-BP association in cross-sectional data leaves open causality and clinical utility; prospective studies required before practice consideration.

Association Between Cardiometabolic Index and Blood Pressure: A Cross-Sectional Analysis of the NHANES 2015–2018 Data

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Association Between Cardiometabolic Index and Blood Pressure: A Cross-Sectional Analysis of the NHANES 2015–2018 Data

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider