What question did this study set out to answer?

Design and synthesize a photoaffinity analog of taxol to covalently probe and identify its binding site on microtubules.

February 1, 1993Journal of Medicinal Chemistry

Synthesis of a photoaffinity analog of taxol as an approach to identify the taxol binding site on microtubules

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Design and synthesize a photoaffinity analog of taxol to covalently probe and identify its binding site on microtubules.
Synthesized a photolabile derivative of taxol functionalized for covalent cross-linking upon irradiation.
Evaluated the analog as a chemical tool to map specific drug-binding interfaces on polymerized tubulin.
Successfully prepared a functional photoaffinity taxol analog capable of selective photolabeling.
Provided a chemical probe strategy to resolve the precise molecular interaction site of taxol on microtubules.

Authors

JCJoan M. CarboniBristol-Myers Squibb (United States)VFVittorio FarinaUniversity of Pisa SRSrinivasa P. S. RaoNovartis (Switzerland)

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Implication

Biochemical study demonstrates synthesis of a photoaffinity taxol analog for microtubule binding, highlighting a chemical probe strategy to map antineoplastic drug target sites.

Cite This Study

Carboni et al. (1993) studied this question.

synapsesocial.com/papers/6a73a47375bfeae413a731af https://doi.org/10.1021/jm00056a013

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Implication

Biochemical study demonstrates synthesis of a photoaffinity taxol analog for microtubule binding, highlighting a chemical probe strategy to map antineoplastic drug target sites.

Synthesis of a photoaffinity analog of taxol as an approach to identify the taxol binding site on microtubules

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Discussion

Implication

Cite This Study

Synthesis of a photoaffinity analog of taxol as an approach to identify the taxol binding site on microtubules

Key Points

Discussion

Implication

Cite This Study

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