Key result
Endothelial pretreatment with IL-1 or TNF transiently increases tumor cell adhesion, peaking at 4-6 hours.
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We report that IL 1 acts on the endothelium, inducing a long-lasting increase in its adhesivity to tumor cells. Selective pretreatment of cultured human umbilical vein endothelial cells (EC) with IL 1 caused a significant increase in adhesion of three human colorectal carcinoma (HT-29, HCC-P2988, and HCC-M1410) cell lines and one human melanoma (A-375) cell line. Tumor necrosis factor (TNF) was as effective as IL 1 in promoting tumor cell adhesion to EC, whereas IFN gamma and IL 2 were inactive. The IL 1 and TNF induction of EC adhesivity was both concentration (threshold concentration 1 U/ml) and time dependent (peak 4-6 h), reversible within 24 h, and blocked by a protein synthesis inhibitor. The IL 1 and TNF action on EC may play a role in tumor cell lodgement.
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Dejana et al. (1988) studied Colorectal carcinoma and melanoma tumor cell adhesion to vascular endothelium. Interleukin 1 (IL-1) and Tumor Necrosis Factor (TNF) vs. IFN-gamma and IL-2 was evaluated on Adhesion of tumor cells to cultured human umbilical vein endothelial cells. Pretreatment of endothelial cells with IL-1 or TNF increased tumor cell adhesion, peaking at 4-6 hours and reversing within 24 hours.
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