What question did this study set out to answer?

To report a case of severe, life-threatening metformin-induced lactic acidosis in a diabetic patient with end-stage renal disease and review the relevant literature on biguanide toxicity.

November 1, 1992Archives of Internal Medicine

Biguanide-associated lactic acidosis. Case report and review of the literature

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Authors

SGShenglian GanThe First People's Hospital of Changde

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Implication

Case report and literature review demonstrates severe biguanide-associated lactic acidosis in a patient with renal failure, highlighting the risks of metformin use in kidney disease.

Key Points

To report a case of severe, life-threatening metformin-induced lactic acidosis in a diabetic patient with end-stage renal disease and review the relevant literature on biguanide toxicity.
Documented the clinical presentation, laboratory values, and emergency management of a diabetic male with end-stage renal failure hospitalized with severe acidosis secondary to metformin.
Reviewed published literature regarding the pathogenesis, clinical features, and therapeutic strategies for biguanide-associated lactic acidosis.
Arterial blood gas evaluation on presentation revealed profound acidemia with a blood lactate of 10.9 mmol/L, a pH of 6.76, and a bicarbonate concentration of 1.6 mmol/L.
Treatment with hemodialysis, volume expansion, supplemental oxygen, and supportive therapies resulted in complete clinical recovery and subsequent hospital discharge.

Cite This Study

Shenglian Gan (1992) studied this question.

synapsesocial.com/papers/6a73aaeb1aa2fc9e78fb6e77 https://doi.org/10.1001/archinte.152.11.2333

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Implication

Case report and literature review demonstrates severe biguanide-associated lactic acidosis in a patient with renal failure, highlighting the risks of metformin use in kidney disease.

Biguanide-associated lactic acidosis. Case report and review of the literature

Discussion

Member takes

Implication

Key Points

Cite This Study

Biguanide-associated lactic acidosis. Case report and review of the literature

Discussion

Member takes

Implication

Key Points

Cite This Study

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