Why the study?
Unilateral carotid body denervation has been proposed for sympathetic hyperactivity-related disorders, but its therapeutic effectiveness depends on whether compensatory chemoreflex plasticity emerges in remnant carotid and aortic afferents.
Highlights the potential for compensatory chemoreflex plasticity following unilateral carotid body denervation, which may limit its long-term therapeutic effectiveness for sympathetic hyperactivity.
Integrity of central afferents may prevent compensatory plasticity after unilateral carotid body denervation; leaves open therapeutic durability in sympathetic hyperactivity disorders.
Unilateral carotid body denervation has been proposed as treatment for sympathetic hyperactivity-related human disorders. Its therapeutic effectiveness for maintaining a persistent decrease in the sympathetic outflow activity will depend on the absence of compensatory chemoreflex plasticity in the remnant carotid and aortic afferents. Here, we suggest that the integrity of central afferents after carotid body denervation is essential to prevent the emergence of plastic functional changes on the contralateral "intact" carotid nerve.
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Eugenı́n et al. (2020) studied this question.
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