Why the study?
What are the long-term effects of iatrogenic carotid baroreceptor denervation on cardiovascular responses to stress in humans?
Population
Humans with iatrogenic bilateral denervation of carotid sinus baroreceptors
Design
Review
Follow-up
long-term
Authors
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Supports monitoring BP variability long-term after baroreflex failure; leaves open whether sympathetic hyperactivity persists beyond the acute phase in humans.
What are the long-term effects of iatrogenic carotid baroreceptor denervation on cardiovascular responses to stress in humans?
While iatrogenic carotid baroreceptor denervation causes long-term increases in blood pressure variability, the severe unopposed sympathetic activation seen initially is limited to the acute phase.
Timmers et al. (2004) studied this question.
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