Key result
Bilateral carotid body tumor resection attenuated heart rate baroreflex sensitivity compared to healthy controls (3.68 vs 11.61 ms/mm Hg; P=0.011).
Why the study?
Does bilateral carotid body tumor resection impair baroreflex control of sympathetic nerve activity compared to healthy controls?
Population
5 patients after bilateral carotid body tumor resection and 6 healthy control subjects.
Comparison
Status post bilateral carotid body tumor resection vs Healthy control subjects
Design
Cohort
Authors
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Bilateral carotid body tumor resection was associated with reduced heart rate baroreflex sensitivity; leaves open effects on sympathetic control and clinical outcomes.
Case-Control (n=11)
Does bilateral carotid body tumor resection impair baroreflex control of sympathetic nerve activity compared to healthy controls?
Absolute Event Rate: 3.68% vs 11.61%
p-value: p=0.011
Denervation of carotid sinus baroreceptors from bilateral carotid body tumor resection produces chronic impairment of baroreflex control of both heart rate and sympathetic nerve activity.
Timmers et al. (2003) conducted a case-control in Bilateral carotid body tumor (n=11). Bilateral carotid body tumor resection vs. Healthy control subjects was evaluated on Heart rate baroreflex sensitivity (phenylephrine) (p=0.011). Bilateral carotid body tumor resection attenuated heart rate baroreflex sensitivity compared to healthy controls (3.68 vs 11.61 ms/mm Hg; P=0.011).
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